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2010 Research Grant Recipients


Eduardo H. Moriyama, BSc, MSc, Ph.D.

Ontario Cancer Institute

Toronto, Canada

Supporting ASLMS Member

James E. Boggan, M.D.

~ Recipient of ASLMS Funding in 2009 and 2010 ~

“Novel Optical Probes for Image-Guided Tumor Resection and Photodynamic Therapy Based on Glucose Transporters”

Tumors often present a shift in metabolism to a less efficient glycolysis. This has been employed diagnostically, using Fluorodeoxy-D-Glucose Positron Emission Tomography (FDG-PET). We propose to synthesize fluorescently-labeled deoxyglucose analogues (F*-DG), whose potential usefulness is 2-fold. Firstly, they could provide high contrast for fluorescence imaging, in particular to improve fluorescence image guided resection (FGR) of tumors. FGR effectively ‘extends the surgeon’s vision’, so that small amounts of residual tumor that are not normally visible can be detected and removed. We will develop this initially for brain tumors, building on previous work, but the concept is widely applicable to any solid tumor that invades the normal host tissue, such as oral tumors that will be a second target. Secondly, we will test the performance of F*-DG probes as photodynamic sensitizers to improve the effectiveness and selectivity of PDT in these tumors.


Martin Purschke, Ph.D.

Massachusetts General Hospital/Wellman Center for Photomedicine

Boston, MA

Supporting ASLMS Member

R. Rox Anderson, M.D.

We would like investigate the ATBE with this grant proposal and divide the proposal in two parts: The first part will focus on the mechanism and selectivity of the ATBE by confirming our preliminary data and hypothesis. The second part will focus on in vivo the laser induced ATBE in 3D or skin models to prove the relevance of the ATBE under more complex in vivo conditions (presents of ROS, scavengers and other biomolecules). With the knowledge of the research funded by this grant, we believe it will help in the design of a new laser application for cancer therapy. Laser treatment could be applied, combined or adjuvant to conventional cancer therapies to increase the overall tumor regression. Furthermore, the obtained data may also have profound impact on the treatment paradigms for laser assisted cancer ablation, e.g. laser assisted thermal therapy.


The American Society for Laser Medicine and Surgery is the world’s largest scientific organization dedicated to promoting research, education and high standards of clinical care in the field of medical laser applications. It provides a forum for the exchange of scientific information and participation in communicating the latest developments in laser medicine and surgery to clinicians, research investigators, government and regulatory agencies, and the public.

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