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2011 Research Grant Recipients


Kimberly R. Byrnes, Ph.D.

Uniformed Services University

Bethesda, MD

Supporting ASLMS Member

Raymond J. Lanzafame , M.D., M.B.A.

Modulation of Microglial Activation with Laser Therapy”

The biological effects of laser therapy (LT), also known as low level light therapy, are currently theorized to follow the Arndt-Schulz law, in which low to moderate energy densities induce activity while higher doses result in inhibition. However, in microglia, there is a range of possible responses, including activation into either a pro-inflammatory (M1) or an anti-inflammatory (M2) state, rather than simple activation and inhibition, excluding them from the Arndt-Schulz law. We therefore aim to show that LT at 810 nm has a differential effect on microglial activation state, depending on energy density. Specifically, we hypothesize that activation of microglia at a low power density will induce an M1 microglial phenotype, while a higher power density will induce an M2 phenotype. These studies will determine if LT can non-invasively modulate microglial phenotype after injury, which would have significant therapeutic potential in the traumatic brain and spinal cord injury fields.


Marlon S. Mathews, M.D.

University of California

Irvine, CA

Supporting ASLMS Member

Steen Madsen, Ph.D.

"Photochemical Internalization (PCI) Enhanced Nonviral Transfection of Tumor Suppressor Genes; a Potential Treatment Modality for Glioma"

The object of the proposed research is the evaluation and optimization of photochemical internalization (PCI) as a site specific method to increase transfection rates of two tumor suppressor genes, PAX6 and PTEN.


The American Society for Laser Medicine and Surgery is the world’s largest scientific organization dedicated to promoting research, education and high standards of clinical care in the field of medical laser applications. It provides a forum for the exchange of scientific information and participation in communicating the latest developments in laser medicine and surgery to clinicians, research investigators, government and regulatory agencies, and the public.

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