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Baharak Bahmani, B.S., M.S.
University of California
Riverside, CA
Supporting ASLMS Member
Jennifer K. Barton, Ph.D.
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“Laser-Mediated Photothermal Destruction of Ovarian Cancer Cells using ICG-loaded Nanocapsules Functionalized with Anti-HER2”
As a first step to determine the efficacy of ICG-NCs for photothermal destruction of peritoneal ovarian cancer cells, the project is aimed at functionalizing ICG-NCs to target and thermally destroy cancer cells in-vitro. Specifically, due to over-expression of Human Epidermal Growth Factor Receptor 2 (HER-2), ICG-NCs will be functionalized with anti-HER2. Successful outcomes of these experiments will provide the proof-of-concept data to further pursue ICG-NCs for imaging and photothermal destruction of peritoneal ovarian cancer in animal models, and ultimately in patients.
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Timothy M. Baran, B.S.
University of Rochester – Institute of Optics
Rochester, NY
Supporting ASLMS Member
Thomas H. Foster, Ph.D.
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“Determination of Doxorubicin Concentration in TACE Treatment of Primary Liver Cancers by Fluorescence Spectroscopy”
Intra-tumor drug concentration can have a large effect on the outcome of the therapy. In previous studies, doxorubicin concentration in systemic circulation was measured. However, the concentration in the tumor was not measured. We propose to study this intra-tumor drug concentration directly by use of fluorescence spectroscopy, since doxorubicin is fluorescent.
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Richa Mittal, B.E., M.S.
University of California
Irvine, CA
Supporting ASLMS Member
Petra Wilder-Smith, D.D.S., Ph.D.
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“A minimally-Invasive Approach to the Challenge of Oral Neoplasia”
We hypothesize that the photosensitizer hexyl-aminolevulinic (HAL or HexvixR) – a lipophilic ester derivate of 5-Aminolevulinic acid (ALA) - can be used for photodetection and photodestruction of oral dysplasia.
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Scott M. Thompson, B.A.
Mayo Clinic
Rochester, MN
Supporting ASLMS Member
Roger J. McNichols, Ph.D.
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“Monitoring of Laser Induced Apoptosis with 3D Molecular Bioluminescence Imaging in a Rat Model of Hepatocellular Carcinoma: Pilot Study”
Our specific aim is to determine the feasibility of non-invasive measurement of apoptotic cell death with combined 3D molecular bioluminescence imaging and magnetic resonance imaging following US-guided laser ablation in a rat model of hepatocellular carcinoma.
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