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Non-invasive imaging used to help evaluate laser-resistant port wine stains

Study characterizes features of laser-resistant port wine stain blood vessels to facilitate a tailored laser protocol.

By Emilee Green | Aug 07, 2019

lu-august-editors-choiceWausau, WI (August 7, 2019) – Although lasers are the treatment of choice for port wine stains (PWS), some PWS are laser-resistant. PWS blood vessels that have high blood flow, large diameters, and are located deeply in the skin are difficult to treat with lasers. To guide a tailored laser protocol, this study used in vivo reflectance confocal microscopy (RCM) to characterize the general morphological features of laser-resistant PWS blood vessels, e.g. blood flow, density, diameter, and depth.

The clinical report of this study, published in Lasers in Surgery and Medicine (LSM), the official journal of the American Society for Laser Medicine and Surgery, Inc. (ASLMS), was selected as the August 2019 Editor’s Choice.

The study, led by Jianyun Lu, MD, PhD is titled “Characterization of LaserResistant Port Wine Stain Blood Vessels Using In Vivo Reflectance Confocal Microscopy.”  

“This study aims to investigate the morphological features of laser-resistant port wine stain blood vessels using non-invasive reflectance confocal microscopy, which will guide a tailored laser protocol to target these blood vessels,” said Lu.

The study concluded RCM can be a valuable tool for a prognostic evaluation on laser‐resistant lesions before treatment, thus guiding tailored laser treatment protocols to improve therapeutic outcomes.

Jianyun Lu, MD, PhD is a Professor and the chair of the Dermatology Department at the Third Xiangya Hospital, Central South University, Changsha, China. She is a committee member of the Chinese Society of Traditional Chinese Medicine in the Dermatology and Immunology Branch. Her main research interests include the pathogenesis and intervention of atopic dermatitis and vascular malformations, mechanistic studies and clinical applications of medical ozone, and laser treatments for cosmetic skin conditions.  

Editor’s Choice is an exclusive article published in LSM, the official journal of the ASLMS. View the complete manuscript.

The American Society for Laser Medicine and Surgery, Inc. (ASLMS) is the largest multi-disciplinary professional organization, dedicated to the development and application of lasers and related technology for health care applications. ASLMS promotes excellence in patient care by advancing biomedical application of lasers and other related technologies worldwide. ASLMS membership includes physicians and surgeons representing multiple specialties, physicists involved in product development, biomedical engineers, biologists, nurses, industry representatives and manufacturers. For more information, visit

The American Society for Laser Medicine and Surgery is the world’s largest scientific organization dedicated to promoting research, education and high standards of clinical care in the field of medical laser applications. It provides a forum for the exchange of scientific information and participation in communicating the latest developments in laser medicine and surgery to clinicians, research investigators, government and regulatory agencies, and the public.

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