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Long-term study evaluates picosecond laser treatment of facial photoaging in Asian skin

Treatment using picosecond alexandrite laser with a diffractive lens array can delay the formation of pigmentation and combat skin aging.

By Emilee Green | Mar 17, 2021

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Wausau, WI (March 17, 2021) – The picosecond alexandrite laser (PSAL) has been clinically proven to be effective in treating photoaging. It delivers short pulses of energy over 550–750 picoseconds, which creates greater photomechanical damage and reduces nonspecific photothermal effects. When used in conjunction with specialized optics called diffractive focus lens array (DLA), the optical breakdown induced during the process can further stimulate collagen and elastin.

At present, there is a lack of high-grade evidence-based studies on the treatment of skin rejuvenation by PSAL with a DLA. Its long-term efficacy has been a controversial topic due to its relatively new status and thus shorter follow-up times. This research is the first prospective, split-face, self-controlled comparative study with the longest follow-up time to prove the efficacy and safety of PSAL with a DLA system for treating photoaging in Asian skin.

This clinical report, published in Lasers in Surgery and Medicine (LSM), the official journal of the American Society for Laser Medicine and Surgery, Inc. (ASLMS), was selected as the March 2021 Editor’s Choice.

The study, carried out by a team from the Department of Dermatology and Department of Laser and Aesthetic Medicine at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, is titled “ThreeYear Results of Facial Photoaging in Asian Patients After Alexandrite 755 nm Picosecond Laser with Diffractive Lens Array: A SplitFace, SingleBlinded, Randomized Controlled Comparison.”  

Split‐face areas were delineated on each patient; one side was randomly treated with PSAL in conjunction with DLA, the other side was left untreated. Ten sessions in total were conducted 2 weeks apart. The results demonstrate that a series of 10 treatments delivered at 2‐week intervals provided long‐term beneficial rejuvenating effects.

The authors, Wenyou Yu, MD; Jiafang Zhu, MD; Wenxin Yu, MD, PhD; Ying Shang, MD; Dongze Lyu, MD; Xiaoxi Lin, MD, PhD; Hui Xu, MD, PhD; and Zhen Zhang MD, PhD are all from the Department of Dermatology and Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China, and are experienced in dermatology and laser surgery.

Editor’s Choice is an exclusive article published in LSM, the official journal of the ASLMS. View the complete manuscript.

The American Society for Laser Medicine and Surgery, Inc. (ASLMS) is the largest multidisciplinary professional organization dedicated to the development and application of lasers and related technology for health care applications. ASLMS promotes excellence in patient care by advancing biomedical application of lasers and other related technologies worldwide. ASLMS membership includes physicians, surgeons, nurses and allied health professionals representing multiple specialties, physicists involved in product development, biomedical engineers, biologists, industry representatives and manufacturers. For more information, visit


The American Society for Laser Medicine and Surgery, Inc. is the world’s largest scientific organization dedicated to promoting research, education and high standards of clinical care in the field of medical laser applications. It provides a forum for the exchange of scientific information and participation in communicating the latest developments in laser medicine and surgery to clinicians, research investigators, government and regulatory agencies, and the public.

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