find a Clinician/Physician

Combination therapy proves to be an effective treatment for complex vascular malformations.

Study demonstrates success using a combination of surgical, laser, and topical and intralesional therapies.

By Emilee Green | Jul 14, 2021

Gerald Goldberg, MD

Wausau, WI (July 14, 2021) – Complex vascular malformations, including capillary and venous malformations, are highly resistant to single modality treatment with vascular lasers. Combination multimodality therapy with surgical debulking, laser technologies, and topical and injection therapies may improve outcomes in nodular hypertrophic and mixed complex vascular malformations; however, there is a paucity of data reporting specific combinations of these treatments.

In the clinical report, “Combination Therapy for the Treatment of Complex Vascular Lesions, authors Mitchell Herold, MD and Gerald Goldberg, MD look at 15 cases of complex vascular malformations treated with novel combinations of these modalities.

This study, published in Lasers in Surgery and Medicine (LSM), the official journal of the American Society for Laser Medicine and Surgery, Inc. (ASLMS), was selected as the July 2021 Editor’s Choice.

“Complex and hypertrophic vascular malformations are functionally debilitating and cosmetically distressing to patients,” said Herold. “We aim to share our approach and techniques for treating a series of patients with combinations of debulking surgical procedures, vascular and ablative lasers, and topical and intralesional vascular therapies with excellent results which may improve treatment outcomes for future patients.”

These combination therapies appear to be synergistic and complementary, providing an improved overall result and reaching optimal treatment endpoints with fewer treatment sessions and an excellent safety profile.

Mitchell Herold attended the University of Florida for both undergraduate studies in microbiology and cell science and medical school, where he graduated with honors in research. He completed his residency internship with the University of Central Florida and is currently completing dermatology residency at the University of Arizona.

Editor’s Choice is an exclusive article published in LSM, the official journal of the ASLMS. View the complete manuscript.

The American Society for Laser Medicine and Surgery, Inc. (ASLMS) is the largest multidisciplinary professional organization dedicated to the development and application of lasers and related technology for health care applications. ASLMS promotes excellence in patient care by advancing biomedical application of lasers and other related technologies worldwide. ASLMS membership includes physicians, surgeons, nurses, and allied health professionals representing multiple specialties, physicists involved in product development, biomedical engineers, biologists, industry representatives and manufacturers. For more information, visit


The American Society for Laser Medicine and Surgery is the world’s largest scientific organization dedicated to promoting research, education and high standards of clinical care in the field of medical laser applications. It provides a forum for the exchange of scientific information and participation in communicating the latest developments in laser medicine and surgery to clinicians, research investigators, government and regulatory agencies, and the public.

Connect with ASLMS!