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Less painful treatment for periorbital wrinkles

Study compares the clinical results, side effects, and downtime between thermomechanical fractional injury (TMFI) and non-ablative fractional 1565 laser for the treatment of periorbital wrinkling.

By Emilee Green | Dec 21, 2021


Wausau, WI (December 21, 2021) – Periorbital wrinkling is one of the earliest signs of aging and can be one of the most challenging aesthetic regions to treat. This study compares a new technology, TMFI therapy, with non-ablative fractional 1565 nm laser (NAFL) for the treatment of periorbital wrinkling.

The clinical report, led by Fares Salameh, MD, is titled, “Treatment of periorbital wrinkles using thermo-mechanical fractional injury therapy versus fractional non-ablative 1565 nm laser: A comparative prospective, randomized, double-arm, controlled study.” 

This study, published in Lasers in Surgery and Medicine (LSM), the official journal of the American Society for Laser Medicine and Surgery, Inc. (ASLMS), was selected as the December 2021 Editor’s Choice.

Thermo‚Äźmechanical fractional injury (TMFI) therapy (Tixel®, Novoxel®, Israel) is a new technology that is now being used for facial skin rejuvenation. The Tixel® is a non-laser, non-radiofrequency, thermomechanical fractional skin treatment device intended for cutaneous procedures requiring coagulation of soft tissue; it transfers heat to the skin directly without emitting radiation. Such technology offers a user-friendly method for performing fractional skin treatment. The Tixel® device treatment was found to be an effective and safe modality for the treatment of periorbital wrinkling, with comparable results to the 1565 nm laser but less painful.

“Periorbital wrinkles are an early manifestation of photoaging, starting as early as the third decade of life and often distressing to patients, causing them to seek rejuvenation procedures,” said Salameh. “Our study introduces a new effective and safe alternative treatment for this challenging indication.”

Fares Salameh, MDFares Salameh, MD, is employed as a senior doctor at the department of dermatology, laser and advanced technology clinic and Center for Aesthetic Dermatology at Tel Aviv Sourasky Medical Center, providing patients with leading-edge technological advances in dermatology and aesthetic skin care. Dr. Salameh is an active researcher at the clinical research unit of his department, conducting numerous studies in the field of scar treatment and esthetic dermatology, including international collaborations.

Editor’s Choice is an exclusive article published in LSM, the official journal of the ASLMS. View the complete manuscript.

The American Society for Laser Medicine and Surgery, Inc. (ASLMS) is the largest multidisciplinary professional organization dedicated to the development and application of lasers and related technology for health care applications. ASLMS promotes excellence in patient care by advancing biomedical application of lasers and other related technologies worldwide. ASLMS membership includes physicians, surgeons, nurses, and allied health professionals representing multiple specialties, physicists involved in product development, biomedical engineers, biologists, industry representatives and manufacturers. For more information, visit


The American Society for Laser Medicine and Surgery is the world’s largest scientific organization dedicated to promoting research, education and high standards of clinical care in the field of medical laser applications. It provides a forum for the exchange of scientific information and participation in communicating the latest developments in laser medicine and surgery to clinicians, research investigators, government and regulatory agencies, and the public.

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