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Optimal drug delivery settings to treat dermatological conditions using needle-free jet injectors

Study establishes relevant clinical endpoints to guide physicians to optimal device settings.

By Andrea Alstad | Feb 16, 2022

Wausau, WI (February 16, 2022) – Needle-free jet injectors have been used in dermatological practice for many years for the nearly pain-free transdermal drug delivery for indications such as hypertrophic scars, keloids, and warts. However, predefined clinical endpoints that guide physicians to choose optimal device settings have not been clearly defined. This study successfully evaluated immediate skin responses as clinical endpoints for needle-free jet injector treatments.

The preclinical report, led by Liora Bik, MD, is titled, “Clinical endpoints of needle-free jet injector treatment: An in depth understanding of immediate skin responses.” The report, published in Lasers in Surgery and Medicine (LSM), the official journal of the American Society for Laser Medicine and Surgery, Inc. (ASLMS), was selected as the February 2022 Editor’s Choice.

“In this ex vivo human skin study, we concluded that the immediate skin papule and residual fluid on the skin surface are relevant clinical endpoints for spring- and air-powered needle-free jet injector systems,” Bik said. “These endpoints are indispensable for the successful and safe treatment with needle-free jet injector systems in clinical practice.”

Liora Bik is a medical doctor and PhD candidate at the Dermatology department at Erasmus University Medical Center in Rotterdam, The Netherlands. She specializes in laser dermatology and scar treatments. In her research, she focuses on needle-free drug delivery with pneumatic jet injectors as minimal invasive treatment in dermatological practice.

Editor’s Choice is an exclusive article published in LSM, the official journal of the ASLMS. View the complete manuscript.

The American Society for Laser Medicine and Surgery, Inc. (ASLMS) is the largest multidisciplinary professional organization dedicated to the development and application of lasers and related technology for health care applications. ASLMS promotes excellence in patient care by advancing biomedical application of lasers and other related technologies worldwide. ASLMS membership includes physicians, surgeons, nurses, and allied health professionals representing multiple specialties, physicists involved in product development, biomedical engineers, biologists, industry representatives and manufacturers. For more information, visit


The American Society for Laser Medicine and Surgery, Inc. is the world’s largest scientific organization dedicated to promoting research, education and high standards of clinical care in the field of medical laser applications. It provides a forum for the exchange of scientific information and participation in communicating the latest developments in laser medicine and surgery to clinicians, research investigators, government and regulatory agencies, and the public.

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